| .sid |
Steam Game Data Backup File |
| .ste |
Dreamweaver Site Settings File |
| .scn |
OpenTTD Scenario File |
| .spc |
Software Publisher Certificate File |
| .skm |
SketchUp Materials File |
| .sprite2 |
Scratch 2.0 Sprite File |
| .sgd |
GeneSnap Image File |
| .smp |
SmilePlant Project Data File |
| .spp |
Serif PhotoPlus Picture File |
| .sct |
Windows Scriptlet |
| .sup |
Super Project Definition File |
| .sar |
Sibelius Arrange Style |
| .spe |
SPSS Extension |
| .spr |
Half-Life Sprite File |
| .sprite |
Scratch Sprite File |
| .sim |
Steam Game Backup Information File |
| .s2mv |
StarCraft 2 Map Preview File |
| .scg |
myPM SCG Definition File, ColoRIX image file |
| .sbp |
Sketchbook Express iCloud Image |
| .skitch |
Skitch Image |
| .spj |
PhotoStage Slideshow Project |
| .sfc |
Super Nintendo ROM |
| .spa |
MikuMikuDance Sphere Mapping File |
| .sph |
NIST SPHERE Audio File |