| .sc2bank |
StarCraft 2 Bank File |
| .sc4lot |
SimCity 4 Lot File |
| .sc4desc |
SimCity 4 Description File |
| .sii |
18 Wheels of Steel: Haulin' Truck Definition File |
| .schematic |
MCEdit Schematic File |
| .spb |
Flight Simulator Mission File |
| .smd |
Valve Studiomdl Data File |
| .sco |
OMSI Scenery Object Configuration File |
| .s2z |
Heroes of Newerth Game Data File |
| .sfc |
Super Nintendo ROM |
| .spk |
Deer Hunter Map File |
| .sga |
Relic Entertainment Game Archive |
| .sdz |
Spring Content Package |
| .spa |
MikuMikuDance Sphere Mapping File |
| .sfar |
Mass Effect 3 DLC File |
| .sff |
M.U.G.E.N. Sprite File |
| .sd7 |
Spring Content Package |
| .sami |
Grand Theft Auto San Andres Mod Installer File |
| .sli |
OMSI Spline Configuration File |
| .sgpbprj |
Baltie Project |
| .sg0 |
Humongous Entertainment Game Save File |
| .spo |
Spore Saved Game |
| .sst |
Serialized Certificate Store File |
| .s2m |
The Settlers 2 Map File |