| .eng |
Chess Engine |
| .egm |
Enigmo Custom Game File |
| .esg |
Enigmo Saved Game File |
| .ecw |
Enhanced Compression Wavelet Image |
| .e2gm |
Pangea Enigmo 2 Custom Game File |
| .ecl |
Touhou Stage Script |
| .esp |
Elder Scrolls Plugin File |
| .edat |
E-DataAid 1.x File |
| .ess |
The Elder Scrolls Saved Game |
| .escape |
Prison Architect Escape Mode Save File |
| .epk |
LG Firmware Package |
| .elm |
Eternal Lands Map File |
| .erp |
Alter Ego Game Archive |
| .euf |
Unified Emulator Format file |
| .est_uax |
Spanish Unreal Audio Package |
| .ekx |
Encrypted 3DS Pokémon Save File |
| .ek6 |
Generation 6 Pokémon Save File |
| .exc |
Black & White Zone File |
| .evp |
Talisman Online Game Data File, Electronic Voice Phenomenon, Earthview configuration file |
| .ewl |
EclipseCrossword Word List File |
| .eix |
Metin2 Game Data File |
| .epc |
Doctor Who Game Data File |
| .eepf |
EmuOS Exchangeable Packet File |
| .frm |
Form File |